Sciatica: disc prolapse / nerve root compression / low back pain / disc bulge The sciatica nerve is the largest and longest nerve in the human body, running from the lower back down through the buttocks and legs to the feet. Sciatica is a condition that occurs when the sciatic nerve is compressed or irritated, leading to pain, numbness, tingling, or weakness in the lower back, buttocks, legs, or feet. This can be caused by a variety of factors, such as a herniated disc, spinal stenosis, degenerative disc disease, or a muscle spasm. Treatment for sciatica depends on the underlying cause, but may include pain relief medication, physical therapy, exercises, hot/cold therapy, can be treated non- surgically also. It is important to seek medical attention if you are experiencing sciatic pain, as it can be a sign of a more serious underlying condition.